Diseases originating in the liver, including non-alcoholic steatohepatitis, can cause abnormal results on liver function tests as well. One reason for having an abnormal liver function test is infection. Among patients with incidental abnormal liver function tests (LFT), further evaluations of HBs antigen, HCV antibody, liver sonography and liver biopsies (if noted in the charts or as reported by the patients) were collected in the third questionnaire. Methotrexate should be discontinued in any patient who displays persistently abnormal liver function tests and refuses liver biopsy or in any patient whose liver biopsy shows moderate to severe changes (Roenigk grade IIIb or IV). Methotrexate Stopped due to Liver Function Test Results and am worried about the outcome of the MRCP scan. To top it all my rheumatologist appointment in August. Keywords: rheumatoid arthritis, psoriatic arthritis, methotrexate, leflunomide, liver function tests, hepatotoxicity Introduction Safety is a common concern among rheumatologists when using non- and biologic-DMARDs in the contemporary era for treatment of rheumatoid (RA) and psoriatic (PsA) arthritis. PubMed Citation (Recommended liver biopsy before starting methotrexate and repeat liver biopsy based upon abnormal liver tests and proposed a five-point grading system from normal [Grade I] to cirrhosis [Grade 5]). clinical Liver function tests 114 Reprinted from AustRAliAn FAmily PhysiciAn Vol.40, no. 3, mARch 2011 the age of 50 years, vitamin D deficiency, Most tests measure hepatocellular damage rather than function, so they are rather misnamed. True liver function tests (LFTs) are those that measure synthesis of proteins made by the liver (albumin, clotting factors) or the liver's capacity to metabolise drugs [1]. Abnormal LFTs do not necessarily Summary. Liver function test abnormal is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 1 - 2 years, also take medication Enbrel, and have Psoriatic arthropathy.